French star Sendawar will miss Saturday's Juddmonte Lockinge Stakes.
Trainer Alain de Royer Dupre withdrew the colt at today's 48-hour final declaration stage for the Newbury showpiece.
His four-year-old, winner of three Group One races last season, has an alternative engagement in the Prix d'Ispahan at Longchamp on Sunday.
Last year's winner Fly To The Stars was also taken out of the £135,000 Lockinge today, with Godolphin relying upon Aljabr and Worldly Manner.
Other withdrawals were Alrassaam and Saffron Walden - whose absence allows jockey Michael Kinane to maintain his association with Amanda Perrett's dual recent Pattern race winner Indian Lodge.
Also in a final field of seven are Almushtarak, Sugarfoot, Trans Island and Golden Silca.
De Royer Dupre explained the decision to run Sendawar in the Prix d'Ispahan rather than the Lockinge.
"It will be his first race of the season and it's a long trip to go to England. I prefer for the beginning to stay in France," he said.
But de Royer Dupre plans to run last year's French 2000 Guineas and St James's Palace Stakes winner in England at some stage this season.
"Maybe the Sussex Stakes or the Eclipse and the Queen Elizabeth II Stakes at the end of the season. In France there is the Prix Jacques le Marois and the Moulin."
Sendawar is one of just five horses left in the Group One Prix d'Ispahan, the only British acceptor being the Mick Ryan-trained Diamond White.
Kamil Mahdi has capitalised on Sendawar's absence to book the French-trained horse's regular partner Gerald Mosse for Almushtarak.
"I think Almushtarak will run a good race. He's in good form and he's crying out to win a Group One this horse," said the Newmarket trainer.
Almushtarak was third to Fly To The Stars in the Lockinge 12 months ago and occupied the same position behind one of tomorrow's rivals Indian Lodge in the KLM UK Mile at Sandown on his seasonal debut last month.
Godolphin have finalised their riding plans with Frankie Dettori on last year's Champagne Lanson Sussex Stakes winner Aljabr and Daragh O'Donohoe aboard Worldly Manner.
