Crimplene followed on her recent German 1,000 Guineas success when defeating Ballydoyle hope Amethyst and locally-trained Storm Dream in the Entenmann's 1,000 Guineas.
Sent off at 16/1, Clive Brittain's filly, who also finished 3rd in the Italian equivalent, stayed on well up front from the 2f pole under a determined drive from Philip Robinson to score by 1 1/2L.
'She would have won also in Italy but for the stalls handlers who gave her a hiding loading up. She'll have a rest and go for the Coronation Stakes,' Britain said.
Newmarket maiden winner Meiosis was sent off the 7/2f but could finish only 9th (found to be slightly lame off fore) while Preseli lost her unbeaten tag back in 12th.
Dermot Weld and Pat Smullen, successful with top-weight Pine Dance (7/1) in the 1m handicap, completed a double when Jammaal (4/1-5/1) landed the Silver Stakes.
'He's tough and consistent and the blinkers helped him concentrate. He's in the Irish Derby but the G2 International Stakes over 1m1f on that day is more likely,' said Weld.
Last season leading 3yo Montjeu (4/9-1/3f) opened his seasonal account in the G1 Tattersalls Gold Cup when coming home in impressive fashion from Greek Dance.
Supporters had a few anxious moments when Mick Kinane, who bided his time aboard John Hammond's colt, had to wait until well inside the final furlong for a narrow gap to open.
Once Kinane asked a question he quickened up in great style to settle the issue in a matter of strides before then surviving a subsequent stewards enquiry.
'The best,' was Kinane's summing up of the victory while John Hammond said, 'He's a very good horse, maybe a great horse and he'll run in the Grand Prix de St Cloud on July 2nd next.'
Aidan O'Brien introduced another promising newcomer in the shape of Darwin (2/5-4/11f) who opened his account in great style in the opening 6f maiden.
'Michael said he was raw but when he knows his job he'll be serious. We'll have a look at the Coventry Stakes at Royal Ascot,' said O'Brien.
Racing concluded with Winged Hussar (8/1) winning the valuable 1m4f handicap for John Oxx and John Murtagh, a 40th success for Dundalk Racing Club.
Earlier Antrim Coast, off the track for 427 days, won the 6f handicap under Dubliner Jason Behan to supply Con Collins with his second success of the weekend.
BF