The 1998 Vodafone Derby winner High-Rise has been forced into retirement after sustaining an injury on his recent US debut.
He reportedly fractured a sesamoid in the Manhattan Handicap at Belmont Park in New York a fortnight ago.
"He's sound, he's walking fine, but his racing career is over," American trainer Kiaran McLaughlin told the Racing Post.
High-Rise was trained by Luca Cumani when he gained a head victory from Godolphin's City Honours at Epsom under Olivier Peslier.
The colt was unbeaten at that stage after wins previously at Doncaster, Pontefract and in the Lingfield Derby Trial.
He went on to finish a length second to Swain in the King George VI And Queen Elizabeth Diamond Stakes but managed only seventh in the Prix de l'Arc de Triomphe at Longchamp.
High-Rise was then controversially moved to Godolphin while being prepared for the Breeders' Cup, and failed to win a race in 1999.
Success in a Listed race in Dubai earlier this year made him only the second Derby winner to score as a five-year-old since 1900, after Quest For Fame.
But he could manage only third behind Fantastic Light in the Dubai Sheema Classic, after which he moved from Saeed bin Suroor to the USA.
The horse, who remains close to Cumani's heart - "he was a very good winner of the Derby" the trainer said - won five of his 13 career starts and earned around £1.25million in prize money.
Olivier Peslier, who rode High-Rise at Epsom, recalled: "It is my best memory of England.
"He was a nice horse and I was on him when he was second to Swain - that was probably his best run.
"I was very happy on this horse. I hope he has some good foals for the future and I would like to ride some of them."
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