Tweedy will bid to follow in the footsteps of her half-brother Duff after claiming the six-furlong conditions race at Dundalk for Eddie Lynam.
Wayne Lordan made all on the daughter of Oasis Dream and she kept on strongly inside the final furlong to post a two-length verdict over Alsalwa
The winner had attracted some support from 11/2 into 4/1. 7/2 favourite Sampers could only finish seventh.
"She did it well. She's a half-sister to Duff and I'd love to get some black-type with her," said Lynam.
"She'll probably go for a Listed race at Lingfield in late November that Duff won before."